Protein Details: Glutamate receptor-interacting protein 2

Protein ID

ICDB_Pro_1689

Protein Name

Glutamate receptor-interacting protein 2

Gene Name

Grip2

Organism

Rattus norvegicus (Rat)

Length

1043 amino acids

AlphaFoldDB

AF-Q9WTW1-F1-model_v4.pdb

Function

May play a role as a localized scaffold for the assembly of a multiprotein signaling complex and as mediator of the trafficking of its binding partners at specific subcellular location in neurons.

Sequence

MLAVSLKWRLGVVRRRPKDDGPYSKGGKDTAGTDGALVCRRQSIPEEFRGITMVELIKREGSTLGLTISGGTDKDGKPRVSNLRPGGLAARSDLLNVGDYIRSVNGIRLTRLRHDEIITLLKNVGERVVLEVEYELPPPAPENNPRIISKTVDVSLYKEGNSFGFVLRGGAHEDLHKSRPLVLTYVRPGGPADREGSLKVGDRLLSIDGIPLHGASHATAIATLQQCSHEALFQVEYDVATPDTVANASGPLVVEIAKTPGSALGISLTTGSHRNKPAITIDRIKPASVVDRSGALHAGDHILAIDGTSTEHCSLVEATKLLASVTEKVRLEILPAPQSRRPLKPPEAVRIQRSEQLHHWDPCVPSCHSPRPSHCRAPTWAPGGQDQSRSVSSTPFSSPTMNPAFPCANASTLPRGPMSPRTTAGRRRQRRKEHRSSLSLASSTVGPGGQIVHTETTEVVLCGDPLSGFGLQLQGGIFATETLSSPPLVRFIEPDSPAERCGLLQVGDRVLAINGIATEDGTMEEANQLLRDAALARKVVLEIEFDVAESVIPSSGTFHVKLPKRRGVELGITISSASRKRGEPLIISDIKKGSVAHRTGTLEPGDKLLAIDNIRLDHCPMEYAVQILRQCEDLVKLKIRKDEDNSDEQESSGAVSYTVELKRYGGPLGITISGTEEPFDPIIISGLTKRGLAERTGAIHVGDRILAINSVSLKGRPLSEAIHLLQVAGETVTLKIKKQLDRPLLPRQSGSLSEASDVDEDPPEALKGGLLTTHFSPAVPSVDSAVESWGSSATEGGFGGSGSYTPQVAVRSVTPQEWRSSRLKSSPPPLEPRRTSYTPGPTDESFPEEEEGDWEPPMSPAPGPAREEGFWRVLGEALEDLESCGQSELLRELEASIMTGTVQSVAVDGRPGSRPWRRSREVGTSPEDLQELLLPTPLEMHRVTLHKDPVRNDFGFSVSDGLLEKGVYVHTVRIDGPAQHGGLQPFDRLLQVNHVRTRDFDCCLAVPLLAEAGDILELVVSRNPLAQSRRTPGAPGPSSPQMI

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Location

Brain specific. Isoform 1 is expressed in the olfactory bulb; cortex and hippocampus and was also expressed at lower levels in thalamus; cerebellum and spinal cord. Isoform 3 is expressed in pyramidal cells of cortex and hippocampus; striatum; thalamus; hypothalamus; stellate cells of cerebellum; and brainstem. Isoform 3 is expressed in pyramidal cells of cortex and hippocampus; striatum; thalamus; hypothalamus; stellate cells of cerebellum; and brainstem. Isoform 3 is expressed in pyramidal cells of cortex and hippocampus; striatum; thalamus; hypothalamus; stellate cells of cerebellum; and brainstem. Isoform 2 and isoform 4 are expressed in cortex; hippocampus; thalamus; cerebellum; brainstem and spinal cord. In hippocampal neurons isoform 4 is found abundantly in spine structures. Isoform 2 is abundant in the cell body and also found in dendritic shafts.

DOI ID

10.1016/s0896-6273(00)80568-1; 10.1016/s0896-6273(00)80706-0; 10.1523/jneurosci.19-16-06930.1999; 10.1523/jneurosci.19-15-06528.1999; 10.1523/jneurosci.22-09-03493.2002; 10.1016/s0896-6273(00)81198-8; 10.1074/jbc.m210010200; 10.1038/ncomms1871

RefSeq

NP_612544.2 [Q9WTW1-1]; XP_006236957.1 [Q9WTW1-2]